Research Article
Connection of Intraoperative Hemolysis with the Development of Cardiac Rhythm Disturbances
Maksimovich Yelizaveta*
Issue:
Volume 14, Issue 2, April 2025
Pages:
28-36
Received:
26 December 2024
Accepted:
22 January 2025
Published:
31 March 2025
Abstract: The use of cardiopulmonary bypass in coronary artery bypass grafting (CABG) surgery can lead to red blood cell damage (hemolysis). Postoperative arrhythmias, such as atrial fibrillation, are frequent and serious complications after CABG. However, the relationship between the hemolysis that occurs during the surgery intraoperative hemolysis and the subsequent development of arrhythmias is not well-understood. This study will examine the connection between the level of IOH and the incidence of cardiac rhythm disturbances in patients with coronary artery disease who have undergone CABG surgery. The mechanisms causing arrhythmias after CABG are complex and involve various factors including changes in blood flow, the damage caused by restoring blood flow after cardiopulmonary bypass, and oxidative stress. Clarifying the role of surgery intraoperative hemolysis could help improve prevention and treatment strategies for these potentially dangerous complications. To establish the connection of IOH with the development of cardiac rhythm disturbances in patients with coronary artery disease after coronary shunting in conditions of cardiopulmonary bypass (CB). All patients underwent CB surgery in a planned manner under IR conditions. According to the level of free hemoglobin [Hb] in blood plasma, which is a marker of the degree of IOH, patients are divided into three groups: group 1 – without IOH (Hb≤ 0.1 g/l), n=43, group 2 - with low IOH (lIOH) - with [Hb]>0.1g/l and <0.5 g/l, n=42, group 3 – with a high IOH (hIOH) corresponded to [Hb] ≥0.5 g/l, n=38.
Abstract: The use of cardiopulmonary bypass in coronary artery bypass grafting (CABG) surgery can lead to red blood cell damage (hemolysis). Postoperative arrhythmias, such as atrial fibrillation, are frequent and serious complications after CABG. However, the relationship between the hemolysis that occurs during the surgery intraoperative hemolysis and the ...
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Research Article
Association Between Clinical and Biochemical Findings of Pediatric Lupus Nephritis and Different Histological Classes
Nafisa Sermin,
Farjana Pervin Nupur*,
Nafisa Abedin,
Tanushree Paul,
Afsana Papry,
Fahmida Hasan Chowdhury,
Rezwana Karim,
Mumtahena Mahmuda,
Nasrin Parvin Labani
Issue:
Volume 14, Issue 2, April 2025
Pages:
37-43
Received:
4 March 2025
Accepted:
19 April 2025
Published:
14 May 2025
DOI:
10.11648/j.cmr.20251402.12
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Abstract: Introduction: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory multisystem disorder which is higher in the pediatric patients than the adult counterpart. The proposed International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification system 2018 stratifies the histomorphological findings of the renal biopsy specimens into different classes that correlates with the clinical and biochemical renal outcome. Methods: This was a cross-sectional observational study conducted at the Department of Pathology, BSMMU. The study included the clinically diagnosed cases of pediatric lupus nephritis, from March 2021 to January 2023. Patients were enrolled by consecutive sampling after fulfilling the inclusion and exclusion criteria. Light microscopy findings of the formalin fixed paraffin-embedded renal biopsy specimens were evaluated and recorded according to the proposed ISN/RPS classification system of LN, 2018. The data were recorded. Ethical measures were maintained throughout the study. The statistical analysis was carried out using the Statistical Package for Social Sciences version 22 for Windows (SPSS Inc., Chicago, Illinois, USA). Before starting this study, the research protocol was being approved by the IRB (Institutional Review Board) of BSMMU, Dhaka. Results: Among 80 patients of LN, majority (67.5%) of the patients belonged to age group 13 to 18 years. The mean age was 13.96 ± 3.09 years ranged from 6 to 18 years. 83.75% of patients were female and 16.25% were male. Class II LN was the most common histological class (32.5%), followed by class IV (27.5%). Majority (46.3%) of the LN patients presented with isolated proteinuria. No clinical presentation was associated with histomorphological classes of LN. UTP and serum creatine were found not significantly associated with histological class of pediatric lupus nephritis. Conclusion: In this study, Class II LN was found to be the most common class of lupus nephritis according to the modified ISN/RPS 2018 classification system.
Abstract: Introduction: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory multisystem disorder which is higher in the pediatric patients than the adult counterpart. The proposed International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification system 2018 stratifies the histomorphological findings of the renal biopsy specime...
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