Clinical Medicine Research

Volume 12, Issue 4, July 2023

  • The Use of Esketamine in Clinical Anesthesia Practice

    Yanqing Song, Rui Zhou

    Issue: Volume 12, Issue 4, July 2023
    Pages: 61-64
    Received: Jun. 03, 2023
    Accepted: Jun. 28, 2023
    Published: Jul. 06, 2023
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    Abstract: Esketamine, a new noncompetitive antagonist of the N-Methyl-D-Aspartate (NMDA) receptor, has been approved by Food and Drug Administration of the United States of America and recently permitted to apply in Chinese medical institutions. By binding to NMDA receptor, esketamine exerts analgesic, sedative and antidepressant effects with no suppression ... Show More
  • Bone Marrow Mesenchymal Stem Cells Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice

    Chunmei Zhang, Chenguang Li, Zhongyan Zhao

    Issue: Volume 12, Issue 4, July 2023
    Pages: 65-71
    Received: Jun. 05, 2023
    Accepted: Jun. 28, 2023
    Published: Jul. 11, 2023
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    Abstract: Objective: The purpose of this study was to investigate the effect of bone marrow mesenchymal stem cells (BMSCs) on bleomycin-induced pulmonary fibrosis in mice. Methods: Pulmonary fibrosis model in mice was established by bleomycin (BLM) induction. This study was divided into 7 groups, bone marrow mesenchymal stem cells (BMSCs) as the treatment me... Show More
  • CADASIL Presenting with Parkinsonism, Intracerebral Hemorrhage, and Atypical White Matter Lesions: A Case Report

    Fan Xinman, Xu Yezi, Zhu Huili, Guo Li, Deng Zhe, Xu Xiaohong

    Issue: Volume 12, Issue 4, July 2023
    Pages: 72-76
    Received: Jun. 25, 2023
    Accepted: Jul. 11, 2023
    Published: Jul. 21, 2023
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    Abstract: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a hereditary cerebrovascular disorder characterized by common clinical manifestations such as frequent migraine episodes, recurrent transient ischemic attacks or strokes, gradual cognitive decline, and emotional disturbances. The typical Magnetic... Show More
  • Comparison of the Brock Model and LU-RADS in Differentiating Benign and Malignant Subsolid Pulmonary Nodules

    Haolei Liu, Weiyun Cao, Haifen Liu, Jun Tan, Xiang Zeng, Shikui Wu

    Issue: Volume 12, Issue 4, July 2023
    Pages: 77-81
    Received: Jul. 02, 2023
    Accepted: Jul. 20, 2023
    Published: Jul. 26, 2023
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    Abstract: Background The Lung Imaging Reporting and Data System (LU-RADS) and the Brock model are commonly utilized tools in clinical practice for evaluating pulmonary nodules. However, both LU-RADS and the Brock model have yet to be validated and compared specifically in subsolid pulmonary nodules (SSN). Therefor, the objective of this study was to compare ... Show More
  • Research Progress of Microglia in the Intervention Effect of Alzheimer's Disease

    Tianying Fang, Caiping Han, Qingli Song, Yaning Hao, Wei Yuan, Meng Yu, Lin Zhang

    Issue: Volume 12, Issue 4, July 2023
    Pages: 82-87
    Received: Jun. 28, 2023
    Accepted: Jul. 24, 2023
    Published: Aug. 22, 2023
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    Abstract: Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by an insidious onset and progressive worsening of cognitive function. The main pathological features of AD are β-amyloid (Aβ) plaques, neuroprogenitor fibril tangles (NFT) formed by hyperphosphorylated Tau proteins, and other pathological features. In ad... Show More
  • Bilateral Congenital Eyelid Eversion: Management of a Case Using the Conservative Approach at the CADESSO of the University Hospital Center, Donka, Conakry, Guinea

    Baldé Abdoul Karim, Bah Thierno Madjou, Diop Mamadou Samba, Zoumanigui Christophe, Camara Sidikiba, Kolié Diariou, Ly Mariame, Cissoko Amadou

    Issue: Volume 12, Issue 4, July 2023
    Pages: 88-90
    Received: Jul. 03, 2023
    Accepted: Jul. 18, 2023
    Published: Aug. 31, 2023
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    Abstract: Introduction: Congenital eversion of the eyelid is a rare palpebral pathology, the first-line treatment for which is the conservative method consisting of the use of artificial tears, antibiotics and bilateral inversion of the eyelids. Observation: We present a clinical observation of a female neonate ten hours old, referred from a peripheral healt... Show More